According to Rueters, two Russian Sukhoi SU-24 warplanes were in the skies above the aid convoy at the time it was struck, but Russia’s foreign ministry spokeswoman denied the assertion, telling reporters at the United Nations that,We have nothing to do with this situation.” 

The attack prompted the United Nations to suspend all aid shipments into Syria. 

EU foreign affairs chef Federica Mogherini and Humanitarian Aid Commissioner Christos Stylianides issued a statement on September 20 calling the air strike alarming violations of international humanitarian law,” as well as saying that, This attack risks setting an unacceptable precedent, jeopardizing the safe delivery of humanitarian aid everywhere.” Mogherini and Stylianides further said, “We call on all parties to the conflict to refrain from any new attack and respect fully the cessation of hostilities. We call in particular on the Syrian government to cease its air campaign against non-terrorist targets in Aleppo, and to allow the immediate and unhindered resumption of humanitarian access to all besieged areas and in particular to the people of Aleppo.” 

Additionally, a report in Rueters has French Foreign Minister Jean-Marc Ayrault saying that Russia and Iran would become “accomplices in war crimes if they continued to prolong the war in Syria.” He called on Russia and Iran “to take their responsibility by stopping this strategy that leads to a dead-end.”  Further, he said,”Otherwise, Russia and Iran will become accomplices of the war crimes committed in Aleppo.” 

UN Secretary-General Ban Ki-moon was reported on September 25 to have said he was appalled by the “chilling” upsurge in fighting in Aleppo and warned that the use of advanced weaponry in Syria’s battleground city could amount to war crimes, citingreports of air strikes involving the use of incendiary weapons, bunker buster bombs and other powerful munitions in the offensive launched by the Syrian army two days ago to recapture the city.  He warned that “the apparent systematic use of these types of indiscriminate weapons in densely populated areas may amount to war crimes,” in a statement from his spokesman.  Ban also said of the air strikes that killed some 45 civilians in Aleppo on Saturday, that he “considers this a dark day for the global commitment to protect civilians.” He urged a clear message to send to the Syrian government that “it will not tolerate the use of indiscriminate and ever more deadly and powerful weapons against civilians.” 

The United States and Russia support opposite sides in the war between Assad’s government and insurgents but are both fighting against Islamic State militants. Washington and Moscow had made a deal to share targeting information.