Police and security teams have cordoned off the crash scene.
Eye witness accounts said the pilot lost control at the end of the runway and crashed the plane into the ground although he managed to take off and fly for seconds. The fuselage smashed into pieces during the incident with the tail landing into a street and the cockpit and front seats smashing into the concrete wall of a glass manufacturing factory.
The plane, operated by Sepahan Air, was heading to Tabas, a town in eastern Iran. It took off at 9:20 a.m. local time (0450 GMT) and crashed shortly afterward.